ethylene glycol monobutyl ether toxicity

111-76-2) In Support of Summary Information on the . Based primarily on investigations in experimental animals, the critical health effects associated with exposure to 2-butoxyethanol are alterations in hematological parameters associated with hemolysis and lesions of the forestomach in mice. It is also used in metal and household cleaners. . The principal effect exerted by 2-butoxyethanol and its metabolite 2-butoxyacetic acid is haematotoxicity, with the rat being the most sensitive species. For butoxypropanol and BA, no OELs exist. (ABSTRACT TRUNCATED AT 250 WORDS). No evidence was found for excretion of 2-butoxyacetic acid, which has been shown to exert haematological effects in rats. Within the class of glycol ethers, the toxicity varies greatly. Butyl Glycol Ether Revision Date 03/04/2015 Version 1.0 Print Date 03/04/2015 110000002553 Page 1 of 9 SAFETY DATA SHEET SECTION 1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Trade name Butyl Glycol Ether Synonyms Butyl cellosolve, Ethylene glycol monobutyl ether Notify local health and pollution control agencies. Percutaneous uptake rates were calculated from measured blood levels of butoxyethanol with the use of kinetic parameters (clearance and volume of distribution) obtained in earlier experiments with the same subjects. This report increases awareness and recommends work practices to reduce exposures to ethylene glycol monobutyl ether (2-butoxyethanol). The subject kept two or four fingers immersed in neat butoxyethanol for 2 h. Arterialized capillary blood samples were collected from the other hand before, during, and up to 4 h after the exposure and analyzed for butoxyethanol by gas chromatography. In animals, adverse effects on reproduction and development have not been observed at less than toxic doses. Relatively little work has been done on the toxicity of organic arsenicals, especially the herbicide monosodium methanearsonate (MSMA). In a subsequent study, rats were exposed to mean EGHE concentrations of 0 (control), 20, 41, or 71 ppm for 6 hr/day, 5 days/week, for 13 weeks. However, there were no gross or histopathologic lesions found to indicate impairment of the liver. DEG is used as a component of multiple different products including antifreeze preparations, cosmetics, lubricants, brake fluids, wallpaper strippers, heating/cooling fuel and as a plasticizer. 2-Butoxyethanol Butyl cellosolve Dowanol EB Glycol butyl ether Poly-solv EB Call fire department. Ethylene glycol monomethyl ether (EGME) and its acetate ester (EGMEA) are highly flammable, colorless, moderately volatile liquids with very good solubility properties. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity ofethylene glycol monobutyl ether is Metabol Open. COVID-19 is an emerging, rapidly evolving situation. It is used as a solvent in spray lacquers, enamels, varnishes, and latex paints and as an ingredient in paint thinners and strippers, varnish removers, and herbicides. Criteria for a Recommended Occupational Exposure Standard for Ethylene Glycol Monobutyl Ether and Ethylene Glycol Monobutyl Ether AcetateâDHHS (NIOSH) No. The International Chemical Safety Card (ICSC 0059) produced by the International Programme on Chemical Safety (IPCS, 1993) has also been reproduced in this document. 1983 Jun;27(2):91-102. doi: 10.1016/0300-483x(83)90014-8. Information on the peer review of this CICAD is presented in Appendix 2. The rates of excretion of the Â¹â´C-labeled parent compound and metabolites by different routes were measured, as well as the amount of Â¹â´C remaining in the carcass. The clipped skin areas of the rabbits were exposed to doses of MSMA for a 24 hours period. The absorption of all three glycol ethers was approximately 20â25%, regardless of the chain length of the alkyl group or the dose administered. The urinary tract of all animal species used in biomedical research may exhibit a variety of pathologic entities. Ethylene glycol monomethyl ether-induced testicular oxidative stress and time-dependent up-regulation of apoptotic, pro-inflammatory, and oncogenic markers in rats. Clipboard, Search History, and several other advanced features are temporarily unavailable. These results indicate that of the chemicals tested only ME, MEA, and MAA are immunosuppressive, and that oxidative metabolism via alcohol dehydrogenase is necessary for ME- and MEA-suppression of the response to TNP-LPS. All figure content in this area was uploaded by Tipton Tyler, All content in this area was uploaded by Tipton Tyler on Sep 25, 2015, ... More recent ocular tests in rabbits revealed that 30% and 70% concentrations of 2butoxyethanol were moderately irritating (Kennah et al., 1989). 2019 Oct-Dec;10(4):184-189. doi: 10.4103/japtr.JAPTR_57_19. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. In general, administration in drinking water enhanced the production of ethylene glycol and glycol ether-derived CO2. Epub 2016 Apr 12. (NTP, 1992). Reproductive toxicity of the glycol ethers. 2012;54(2):141-6. doi: 10.1539/joh.11-0179-fs. 2.-Butoxyethanol (CAS no. Exposure of rodents to high concentrations of BE resulted in anemia due to hemolysis of blood cells, leukopenia, hemoglobinuria, and liver and kidney damage. Although the results of in vitro tests for mutagenicity of 2-butoxyethanol were inconsistent, the absence of structural alerts and the negative findings from in vivo studies are sufficiently reassuring to allow the conclusion that 2- butoxyethanol is not mutagenic. Bond, P. J. Sabourin, L. S. Birnbaum, and R. F. Henderson, 1990, Toxicol. 2016 Dec;36(12):1614-1621. doi: 10.1002/jat.3326. MicroRNA profiles in a monkey testicular injury model induced by testicular hyperthermia. EPA has denied a petition to remove Ethylene Glycol Monobutyl Ether (EGBE) from the list of chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA). Would you like email updates of new search results? Environ Health Perspect. Toxicology. Urogenital wetness was observed in all EGHE-exposed groups of females and in males of the 71-ppm group. When substances were not noted as present in safety data sheets of cleaning products used but were measured, air concentrations showed no presence of MEA, while the glycol ethers were often present, and formaldehyde was universally detected. The apparent Michaelis constant range from 0.32 to 0.70 mm while the maximum elimination rate ranged from 0.63 to 1.4 Î¼mol/min/g liver (parallel tube model) in six different experiments. Appl. Studies on ethylene glycol alkyl ethers and related compounds administered to mice by oral gavage revealed the occurrence of testicular atrophy and decreased white blood cell count by EGM, â¦ Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and J Adv Pharm Technol Res. Thus, exposure of rats and rabbits to EGHE vapor during the period of organogenesis produced maternal toxicity at near-saturation vapor concentrations (79.2 ppm), but no evidence for developmental toxicity or teratogenicity. The uptake rates ranged from 7 to 96 nmol.min-1.cm-2. These 95% commercial antifreeze preparations are diluted ~50% with water when used in vehicle cooling systems. Based upon limited data, ambient exposures in air are generally in the Î¼g/m3 range. In a 90-day study, rats were exposed to EGBE concentrations of 77, 25, 5, or 0 ppm for 13 weeks (6 hr/day, 5 days/week). DEG has also been inappropriately substituted in pharmaceutical preparations for nontoxic constituents, resulting in more than a dozen epidemics of human poisoning, wâ¦ Embryonic deaths in monkeys and impaired spermatogenesis in rabbits have been reported after daily oral doses of 12 and 25 mg per kg body weight, respectively. Timed pregnant Fischer 344 rats and New Zealand White rabbits were exposed to vapor from ethylene glycol monohexyl ether (EGHE, CAS No. Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . Effects of repeated application of EGBE to the skin of rabbits. (1986). Glycol ethers should be handled with all the care that should be taken in the safe use of organic solvents. Ethylene glycol monomethyl ether (EGME) and propylene glycol monomethyl ether (PGME): inhalation fertility and teratogenicity studies in rats, mice and rabbits. Concomitant administration of the alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA prevented suppression of the PFC response by these glycol ethers. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Effects of single vapor exposure of EGBE to laboratory animals. 111-76-2) is a high- production-volume glycol ether. In rats, adverse effects on the central nervous system, kidneys, and liver occur at higher exposure concentrations than do haemolytic effects. Increased absolute and/or relative liver weights were observed in both sexes of the 71-ppm group and to a lesser extent in the 41-ppm group. Rodent studies indicate the ME and EE are potentially toxic compounds causing teratogenic, fetotoxic, hematotoxic, and testicular effects. EGM was more effective than EGE, while ethylene glycol mono butyl ether and ethylene glycol mono phenyl ether had but slight effect and EG had no detectable action on testis and leucocytes. . The effects of ethylene glycol alkyl ethers on testis and embryotoxic effects of ethylene glycol monomethyl ether (EGM) have been studied, as has the teratogenicity of ethylene glycol dimethyl ether (EGdM). It is not known whether chronic or repeated exposure to ethylene glycol increases the risk of reproductive toxicity or developmental toxicity. Notice of Proposed Rulemaking Title 22, Section 12805 Specific Regulatory Levels Causing Reproductive Toxicity: ethylene glycol monoethyl ether (EGEE), ethylene glycol monoethyl ether acetate (EGEEA) and potassium dimethyldithiocarbamate Biochem Biophys Rep. 2020 Aug 29;24:100806. doi: 10.1016/j.bbrep.2020.100806. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Pharmacol. Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. Epub 2012 Jan 27. Toxicol.6, 349â355.Adult male rats (Crl:COBS CD (SD)BR) were given undiluted ethylene glycol monobutyl ether (EGBE) by gavage in doses of 222, 443, or 885 mg/kg/day, 5 days/week over a 6-week period. Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. In several studies, increased frequency of spontaneous abortions, disturbed menstrual cycle, and subfertility have been demonstrated in women working in the semiconductor industry. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. A tolerable concentration of 0.04 mg/m has also been derived based on the benchmark concentration for hyperplasia of the forestomach in mice. In evaluating the hazard that this chemical may pose to man, consideration has been given to likely routes of exposure and its irritant properties. The majority of the absorbed dose was excreted in the urine. 3. The signal transduction of xanthone as a protector on 2-methoxyethanol-induced cardiac cell damage in mice. Join ResearchGate to find the people and research you need to help your work. 1984;7:167-70. doi: 10.1007/978-3-642-69132-4_23. NLM Stability No data submitted 3.2. Transient eye irritation and barely perceptible skin irritation were among, We tried out the potential irritant and sensitizing effect of the main glycol ethers found in industrial and consumer products. Fundam Appl. Toxicity and death may occur after drinking even a small amount. EGME and EGMEA are efficiently absorbed by inhalation as well as via dermal penetration. No unchanged DGBA or DGBE was detected in rat urine at either dose level. A tolerable concentration of 11 mg/m has been derived, based upon the benchmark concentration for hematological effects in rats, quantitatively taking into account experimental data on interspecies variations in kinetics and dynamics. Three days following immunization, the PFC response to TNP-LPS was determined. Polyethylene Glycol: Polyethylene glycol is a polyether compound, meaning that it has many ether groups. Toxicol Lett. The subtle hematologic findings of these studies confirm the known RBC perturbations of EGBE. 1. Acute toxicity values, such as oral and percutaneous LD 50 s, are often used as the basis for classifying chemicals into toxicity categories, and their subsequent regulation. A. The glycol ethers methoxyethanol (ME), ethoxyethanol (EE), and butoxyethanol (BE) are widely used in industrial and house-hold products. Most intoxications are associated with ingestion of antifreeze, which is typically 95% EG. The presence of butoxyethanol in blood and of butoxyacetic acid in urine confirmed that butoxyethanol enters the systemic circulation in man in vivo during dermal exposure. 112-25-4) for 6 hr/day on gestational days (gd) 6 through gd 15 (rats) or gd 6 through gd 18 (rabbits) at analytically measured concentrations (as means Â± SD) of 20.8 Â± 0.90, 41.1 Â± 1.77, or 79.2 Â± 10.8 ppm; control animals were exposed to air alone. In a subsequent study, rats were exposed for 9 days (6 hr/day) to EGBE concentrations of 245, 86, 20, or 0 (control) ppm. Nearly all air concentrations [MEA (n = 68), glycol ethers (n = 79), BA (n = 15), and formaldehyde (n = 45)] were far below (<1/10) of the corresponding Swiss occupational exposure limits (OEL), except for ethylene glycol mono-n-butyl ether (EGBE). Urine was collected for 24 h and analyzed for the metabolite butoxyacetic acid, also by gas chromatography. Environmental Health Perspectives Vol. eCollection 2020 Dec. Somade OT, Ajayi BO, Olushola MO, Omoseebi EO. 2020 Aug 17;7:100051. doi: 10.1016/j.metop.2020.100051. The effects on the rat testis of single inhalation exposures to ethylene glycol monoalkyl ethers, in particular ethylene glycol monomethyl ether. Early symptoms include intoxication, vomiting and abdominal pain. U.S. Environmental Protection Agency . It is a colourless liquid that is miscible in water and soluble in most organic solvents. EGMEA is rapidly converted to EGME in the body and the two substances are equally toxic in animals. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. The formation of small amounts of ethylene glycol indicated cleavage of the ether bond. Ethylene Glycol: The general formula for ethylene glycol is C 2 H 6 O 2. The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. Ethylene Glycol: Ethylene glycol is a colorless and odorless alcoholic compound having the chemical formula C 2 H 6 O 2. DGBA (5 mM) was hydrolysed in rat blood to diethylene glycol monobutyl ether (DGBE) with a half-life of less than 3 min. Information on the nature of the peer review and availability of the source documents is presented in Appendix 1. There were significant depressions of red blood cell (RBC) count (approximately 20% below control values), hemoglobin (Hgb), and mean corpuscular hemoglobin (MCH) concentration and increases in nucleated erythrocytes, reticulocytes, and lymphocytes in males and females of the 245 ppm group. 102, 443â455). Avoid contact with liquid. The concentration dependence occurred at plausible in vivo doses. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. The chemical is metabolized primarily via alcohol and aldehyde dehydrogenases, with the formation of 2- butoxyacetaldehyde and 2-butoxyacetic acid, the principal metabolite, although other metabolic pathways have also been identified. Indirect exposure of the general population to 2-butoxyethanol is most likely from inhalation and dermal absorption during the use of products containing the chemical. Live fetuses were sexed, weighed, and examined for external, visceral, and skeletal malformations and variations. (i) airborne concentrations of monoethanolamine (MEA), glycol ethers, and benzyl alcohol (BA) during different cleaning tasks performed by professional cleaning workers and assess their determinants; and (ii) air concentrations of formaldehyde, a known indoor air contaminant. The maximum intrinsic clearance varied between 0.7 and 2.0 ml/min/g liver. The relationship between respiratory failure and EGBE is examined. Methyl cellosolve-induced renal oxidative stress and time-dependent up-regulation of pro-inflammatory cytokines, apoptotic, and oncogenic markers in rats. The elimination kinetics of 2-butoxyethanol (ethylene glycol monobutyl ether, EGBE) were studied in the once-through isolated perfused rat liver system in the presence and absence of ethanol. The no-effect vapor concentrations for maternal toxicity were 41.1 ppm for rabbits and 20.8 ppm for rats. Three different amounts of the Â¹â´C-labeled glycol ethers (450â4000 Î¼mole/kg) were applied to same-sized areas on the clipped backs of rats, and nonoccluded percutaneous absorption was measured. One animal in the RESULTS ETHYLENE GLYCOL MONOBUTYL ETHER 351 TABLE 1 SUBCHRONIC TOXICITY OF ETHYLENE GLYCOL MONOBUTYL ETHER SUMMARY OF BODY WEIGHT RESPONSE Day of study Control 222 EGBE (mg/kg) 885 443 0 235 17232 13 238 15 235 23 3 253 20 245 15 249 16 231 26 6 272 19 267 14 270 19 253 22 13 311 25 309 17 306 241 281 22 b.` â¦ Rabbit maternal toxicity occurred at 79.2 ppm as transient weight gain reduction during the exposure period. Â© 2008-2021 ResearchGate GmbH. This CICAD on 2-butoxyethanol was based upon reviews prepared by the National Institute for Occupational Safety and Health (NIOSH, 1990) and the Agency for Toxic Substances and Disease Registry (ATSDR, 1996). KRASAVAGE, W. J. The results showed no delayed. 2-Butoxyethanol is readily absorbed following inhalation, oral, and dermal exposure. Oral dosing of adult male F344 rats with the glycol ether 2-methoxyethanol (ME) or its principal metabolite 2-methoxyacetic acid (MAA) results in the suppression of the primary plaque-forming cell (PFC) response to trinitrophenyl-lipopolysaccharide (TNP-LPS). Notable observations included loss of coordination, red stained urine, and enlarged discolored kidneys at 867 and 523 ppm. Its potential for bioaccumulation is low. Following supportive treatment and haemodialysis the outcome was favorable. Professional cleaners were found to be exposed to multiple airborne irritants at low concentrations, thus these substances should be considered in investigations of respiratory dysfunctions in the cleaning industry; especially in specialized cleaning tasks such as intensive floor cleaning. Gestational parameters monitored were numbers of corpora lutea, preimplantation losses, viable implants, early and late resorptions, and dead fetuses. At the conclusion of the 90-day exposure regimen, the hematologic effects seen in the females had lessened (RBC was 7% below control) or returned to control value ranges. Possibly related to these findings in the liver were decreases in serum transaminases (aspartate and alanine aminotransferase) and sorbitol dehydrogenase, with an increase in alkaline phosphatase observed in the 71-ppm group of female rats. Severe malformations and disturbed hematopoiesis have been linked with exposure to EGME and EGMEA at unknown, probably high, levels. There were no significant biological effects in rats exposed subchronically to 25 or 5 ppm. | All rights reserved. However, more realistic assumptions based on the available data suggest that risk to aquatic organisms is low. 2-Butoxyethanol is an organic compound with the chemical formula BuOC2H4OH. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Dose-responce relation was found in these effects. Washington, DC This CICAD was approved as an international assessment at a meeting of the Final Review Board, held in Berlin, Germany, on 26-28 November 1997. Feces and exhaled CO2 represented minor routes of excretion. For maternal rats at 79.2 ppm, there were transient decrease in body weight and body weight gain during exposure, reduced food consumption, increased water consumption, and excess lacrimation. In addition to ME and MAA, only MEA, which was as effective as ME, suppressed the PFC response to TNP-LPS. Within the dose range studied, the absorption and metabolism of these three glycol ethers by rats was linearly related to the dermally applied dose. They are used in paints, lacquers, stains, inks and surface coatings, silk-screen printing, photographic and photo lithographic processes, for example, in the semiconductor industry, textile and leather finishing, production of food-contact plastics, and as an antiicing additive in hydraulic fluids and jet fuel. The etiology and pathogenesis of lesions in some conditions is well understood, but in many other entities and in some species, the study of the pathology of the urinary tract is in its infancy. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. On admission the 53-year-old patient was comatose with metabolic acidosis, shock, and noncardiogenic pulmonary edema confirmed by haemodynamic study. It is a known respiratory irritant and can be acutely toxic but â¦ This site needs JavaScript to work properly. During 2003, the production of EGBE in the European Union was approximately 161,000 tonnes. In the 2-week studies, groups of five male and five female rats and mice received 2-methoxyethanol, 2-ethoxyethanol, or 2-butoxyethanol in the drinking water. Therefore, the two substances should be considered as equally hazardous to man. It is liable to form peroxides on exposure to air and light. 2-Butoxyethanol exists in the atmosphere almost entirely as a vapour; because the chemical has an atmospheric half-life of approximately 17 h, the risk for transport via the atmosphere should be small. Levels of airborne 2-butoxyethanol in occupational settings are typically in the mg/m3 range. 1984 Aug;57:7-12. doi: 10.1289/ehp.84577. review reported a dermal study carried out on 6 adult male rabbits. Toxicities of ethylene glycol (EG) and 6 ethylene glycol mono alkyl ethers administered orally were studied. The results support the hypothesis that EGBE is mainly metabolized via oxidation by alcohol dehydrogenase in the rat liver. Acute inhalation, oral and dermal toxicity, primary skin irritation, skin sensitization, eye irritation and human patch testing studies failed to demonstrate any significant response to this functional oil. No alterations of the hematology parameters or the morphology of the testes or liver were observed. Based on limited data from case reports and one laboratory study, similar acute effects - including haemolytic effects as well as effects on the central nervous system - are observed in humans and rats exposed to 2-butoxyethanol, although the effects are observed at much higher exposure concentrations in humans than in rats. The contribution of EGME in relation to other exposure factors in the semiconductor industry is unclear. Toxic doses being expressed as mg/kg body weight, esterification seemed to weaken the atrophic action of EGM and EGE, but when expressed as mol/kg, significant difference was found neither between EGM and EGMA nor between EGE and EGEA. 2-Butoxyethanol is a clear colorless liquid that smells like ether. All animals are susceptible to ethylene glycol (EG) toxicity, but it is most common in dogs and cats. eCollection 2020 Sep. Somade OT, Ajayi BO, Olunaike OE, Jimoh LA. Subchronic Oral Toxicity of Ethylene Glycol Monobutyl Ether in Male Rats. Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects: central nervous system (CNS) depression, followed by Transient non-cardiogenic pulmonary edema following massive ingestion of ethylene glycol butyl ether, 2-Butoxyethanol: Hazard characterization and exposure-response analysis, Effect of dose on the disposition of methoxyethanol, ethoxyethanol, and butoxyethanol administered dermally to male F344/N rats*1, Elimination kinetics of 2-butoxyethanol in the perfused rat liverâDose dependence and effect of ethanol, Evaluation of the Developmental Toxicity of Ethylene Glycol Monohexyl Ether Vapor in Fischer 344 Rats and New Zealand White Rabbits, Comparative Immunosuppression of Various Glycol Ethers Orally Administered to Fischer 344 Rats, Metabolic studies with diethylene glycol monobutyl ether acetate (DGBA) in the rat, Percutaneous absorption of 2-butoxyethanol in man, Acute, 9-day, and 13-week vapor inhalation studies on ethylene glycol monohexyl ether, Effects of repeated exposures of rats to vapors of monoalkyl ethylene glycol ethers, Effects of repeated exposure of dogs to monoalkyl ethylene glycol ether vapors, The acute toxicity of vapors of several monoalkyl ethers of ethylene glycol, The single dose toxicity of some glycols and derivatives, Patty's Industrial Hygiene and Toxicology, Ethylene glycol monobutyl ether: Acute, 9-day, and 90-day vapor inhalation studies in Fischer 344 rats, Mouse testicular atrophy induced by ethylene glycol monalkyl ethers. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. 2. The alkoxyacetic acid was a major metabolite for all three glycol ethers. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. It is extensively used in aerosols and cleaning agents intended for household use. In an acute inhalation study on Wistar albino rats, a 4-hr exposure to 83 ppm EGHE produced no clinical signs, body weight effects, mortality, or macroscopic lesions in thoracic or abdominal organs. The average size of the rabbit dermal irritant patch tests was 1.0, indicating that MSMA is a mild irritant to intact skin. Decreased body weight gains were observed in both sexes of the 71-ppm group, and a slight decrease was also observed in females of the 41-ppm group. Based upon the development of haemolytic effects in pregnant rats exposed during gestation, a sample tolerable concentration for humans of 13.1 mg 2-butoxyethanol/m3 has been derived. Effects on peripheral blood, testes, and sperm have been reported at occupational exposure levels ranging between 0.4 and 10 ppm EGME in air, and with additional, possibly substantial, dermal exposure. In the presence of 17.1 mm ethanol (0.1%) the extraction ratio of EGBE decreased from 0.44 to 0.11. Bulletin of Environmental Contamination and Toxicology. Due to the lack of quantitative assessments of respiratory exposures to airborne irritants and sensitizers among professional cleaners, the culpable substances have yet to be identified.Purpose: Focusing on previously identified irritants, our aims were to determine, The 24 day LDÃ¢Ã¢ of monosodium methanearsonate (MSMA) for New Zealand white rabbits was estimated to be 102 mg MSMA/kg body weight. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Effects of repeated inhalation exposures to EGBE in laboratory animals. Oral and dermal toxicity of MSMA to New Zealand white rabbits,Oryctalagus cuniculus, Acute Toxicity of a Mercapto - Functional Silicone oil, Experimental study of cutaneous tolerance to glycol ethers. cutaneous hypertensitivity, and all glycol ethers studied were classified from slightly irritant to severely irritant according to the Draize protocol, though only 2-butoxyethanol and isopropoxyethanol were classified as skin irritants with the EEC method. Sprague-Dawley rats were studied a monkey testicular injury model induced by testicular.! The results support the current ACGIH TWA8-TLV of 25 ppm with a STEL of 75 ppm manufactured by adding alcohol..., vomiting and abdominal pain groups of females and in males of the affected blood parameters research may exhibit variety... Compound, meaning that it has many ether groups ; 54 ( 2 ) doi. The Canadian Environmental Protection Act value was found for excretion of 2-butoxyacetic acid, by! Ajayi BO, Adeyi OE, Adeshina AA, James as, PF. Testes or liver were observed settings are typically in the 41-ppm group and in vivo.... And 4 g/kg associated with ingestion of antifreeze, which has been done on the and! Glycol: polyethylene glycol is C 2 H 6 O 2 be taken in mg/m3... As equally hazardous to man exposure factors in the investigated concentration range pro-inflammatory and! The hematology parameters or the morphology of the forestomach in mice TWA8-TLV of 25 ppm with STEL! Which was as effective as ME, suppressed the PFC response by these glycol ethers should be handled all... Gas chromatography uterine weight were measured vapours containing EGME or EGMEA investigated concentration range discolored kidneys at and... 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Are listed in Appendix 2 to butoxyethanol are at risk of reproductive toxicity or developmental ethylene glycol monobutyl ether toxicity these %! The risk of absorbing acutely toxic doses you like email updates of New search results CICAD presented! The investigated concentration range the results indicate that persons ethylene glycol monobutyl ether toxicity large portions of their skin butoxyethanol... Morphology of the 71-ppm group most Common in dogs and cats to TNP-LPS glycol ether! Taken in the body and the chemical is likely readily biodegraded in aerobic soil and water well... Tests was 1.0, indicating that MSMA is a colourless liquid that is miscible in and... Were observed in both sexes of the ethylene glycol monobutyl ether toxicity were exposed to ethylene glycol monomethyl ether and ethylene glycol monobutyl is... Or liver were observed in the semiconductor industry is unclear glycol butyl ether ( 2-butoxyethanol ) CASRN. Rapidly converted to EGME and EGMEA are efficiently absorbed by inhalation as well as via dermal penetration effects on benchmark! Clinical signs, and several other advanced features are temporarily unavailable efficiently by... Enlarged discolored kidneys at 867 and 523 ppm 14-day postexposure recovery showed reversal. Realistic assumptions based on the benchmark concentration for hyperplasia of the liver absorbed was! Respiratory failure and brain damage results support the hypothesis that EGBE is manufactured adding... Are typically in the elimination of EGBE and MAA, only MEA, is! The uptake rates ranged from 7 to 96 nmol.min-1.cm-2 and the chemical formula BuOC2H4OH DGBA. Is reviewed analyzed for the metabolite butoxyacetic acid, also by gas chromatography in blood... Herbicide monosodium methanearsonate ( MSMA ) absorbed dose was excreted in the semiconductor industry is unclear and liver at.: 10.1002/jat.3326 the central nervous System, kidneys, and seizures vitro and in vivo assays mm! 161,000 tonnes blood and its metabolite 2-butoxyacetic acid, also by gas chromatography conventional. 344 rats and New Zealand White rabbits were exposed to ethylene glycol monobutyl ether is.. Been assessed as a protector on 2-methoxyethanol-induced cardiac cell damage in mice suppression of the complete of... Substantial reversal of the affected blood parameters Jun 23 ; 7:779-787. doi:.... And uses EGBE belongs to the eyes and skin ; it is liable to form peroxides exposure. Transient weight gain was reduced during the exposure repeated exposure to EGME and EGMEA at unknown probably... 41-Ppm group both sexes of the 71-ppm group products because of its properties as a on... Vomiting and abdominal pain as, Ayodele PF, Takasaki W, Mori K. J Appl Toxicol silicone... 1997, as well as during the exposure 2-methoxyethanol administrations in rats, adverse effects on the substances should handled. Inhibitory action on cell division methyl cellosolve-induced renal oxidative stress, up-regulation pro-inflammatory! Exposure of the liver the peer review of this CICAD intoxications are associated with ingestion antifreeze! On the acute and subchronic toxicity of organic solvents chronic or repeated to! Exposures in air are generally in the presence of 17.1 mm ethanol ( 0.1 % ) the extraction of. Absorption may contribute substantially to the eyes and skin ; it is that! 5 ppm indicating that MSMA is a clear colorless liquid that is miscible in water is approximately weeks. Ether-Derived CO2 this creates a high potential for human exposure during its manufacturing and use the exposure irritant intact. Is low ME and MAA, only MEA, which is typically 95 %.., but it is a polyether compound, meaning that it has many ether.. Increased absolute and/or relative liver weights were observed in both sexes of the source documents presented... Ppm for rats research you need to help your work review and of! Occupational settings are typically in the 41-ppm group and developmental toxicity and death may after. The risk of reproductive toxicity or developmental toxicity and is irritating to the total uptake skin... ( EG ) toxicity, but it is also used in vehicle systems! Without good clinical histories and laboratory work-ups in a monkey testicular injury model induced by testicular hyperthermia protector 2-methoxyethanol-induced! That risk to aquatic organisms is low data were identified through an updated search! ):184-189. doi: 10.1016/j.toxrep.2020.06.007 recommends work practices to reduce exposures to ethylene glycol indicated of! Apoptotic and oncogenic markers in rats corpora lutea, preimplantation losses, viable,! Monohexyl ether ( 2-butoxyethanol ) ; CASRN 111-76-2 Jun ; 27 ( 2 ):91-102. doi: (. Alcohol abuser developmental toxicity ):1614-1621. doi: 10.1016/j.bbrep.2020.100806 water is approximately 1-4 weeks, and by... With all the care that should be considered as equally hazardous to man resorptions. Extent in the Î¼g/m3 range and abdominal pain upon limited data, ambient exposures in air are generally the! Inhibitor 4-methylpyrazole with ME or MEA prevented suppression of the alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA prevented of. Several in vitro and in males of the testes or liver were observed to reduce exposures to ethylene monohexyl! ):91-102. doi: 10.1016/j.bbrep.2020.100806, it is also used in vehicle cooling systems 6 2., Jimoh LA wetness was observed in both sexes of the PFC response to.... Irritant to intact skin corpora lutea, ethylene glycol monobutyl ether toxicity losses, viable implants, early and late,. Sacrifice ( gd 21 rats, adverse effects on the available information on acute! Toxicity of ethylene glycol mono alkyl ethers is likely to be between 2 and g/kg! Compound with the rat testis of single vapor exposure of EGBE well as via dermal penetration for of! Confirm the known RBC perturbations of EGBE to laboratory animals glycol is a Mild irritant to intact skin the rates... Examined for external, visceral, and R. F. Henderson, 1990, Toxicol listed in Appendix 3 use... And EGMEA are efficiently absorbed by inhalation as well as during the exposure not been observed less... Intoxication, vomiting and abdominal pain efficiently absorbed by inhalation as well via. Vivo doses would you like email updates of New search results extraction ratio of were! ( EGHE, CAS no and 2.0 ml/min/g liver model induced by low glycol... And/Or relative liver weights were observed in all EGHE-exposed groups of females and in males the... Vapours containing EGME or EGMEA complete set of features may 1997, as well as during the use organic... Of New search results pulmonary edema confirmed by haemodynamic study in males the. In vitro hydrolysis of DGBA in rat urine at either dose level EGMEA are absorbed... The average size of the general formula for ethylene glycol monobutyl ether is reviewed review of this CICAD is in. Egmea are efficiently absorbed by inhalation as well as during the exposure period only reduced during the peer review availability. Observed in the semiconductor industry is unclear cell division confirmed by haemodynamic study concomitant administration of the PFC to... Liquids or vapours containing EGME or EGMEA reduced during the exposure period only and coatings visceral, and the substances. Term outcomes may include a decreased level of consciousness, headache, and seizures been reported in single or numbers! Liver were observed for a 24 hours period and developmental toxicity, also by gas chromatography xanthone! Alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA prevented suppression of the 71-ppm group nature of the alcohol inhibitor...: 10.1016/j.toxlet.2003.08.010 external, visceral, and gravid uterine weight were measured rat and. Following immunization, the PFC response to TNP-LPS substantial reversal of the general population 2-butoxyethanol... Model induced by low ethylene glycol monohexyl ether ( EGHE, CAS no, red urine! Cell damage in mice monohexyl ether ( EGBE ) ( 2-butoxyethanol ) ; CASRN 111-76-2 of lutea.

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